Voprosy meditsinskoi khimii (ISSN 0042-8809)

Cyclic AMP and cyclic GMP level in cells of spontaneously aborted fetuses with trisomic and triploid karyotypes

   
Kukharenko V.I., Khokhlova I.V.
PubMed Id: 2554592
Year: 1989 vol: 35  issue:4  pages: 73-75
Abstract: Contents of intracellular cAMP and cGMP were studied in cultivated fibroblasts from 4 spontaneous abortuses with trisomy 7 and trisomy 9 as well as in 4 triploid cell strains. Six diploid cell strains from medical abortuses were used as controls. Distinct increase in cAMP content both calculated per I mg of cell protein or per a cell was found in trisomic strains, whereas the cAMP content increase in triploid strains was detected only per a cell. The data obtained suggest that functions of membrane complexes were impaired in the cells with anomalous karyotype.
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Reference: Kukharenko V.I., Khokhlova I.V., Cyclic AMP and cyclic GMP level in cells of spontaneously aborted fetuses with trisomic and triploid karyotypes, Voprosy meditsinskoi khimii, 1989, vol: 35(4), 73-75.
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