Voprosy meditsinskoi khimii (ISSN 0042-8809)

Interleukin-1 and fibrinolysis. In vivo studies

   
Liutova L.V., Andreenko G.V., Karabasova M.A., Rybakina E.G., Kozinets I.A., Ashmarin I.P.
PubMed Id: 2815683
Year: 1989 vol: 35  issue:4  pages: 75-78
Abstract: Distinct decrease in fibrinolytic activity of both whole blood plasma and its euglobulin fraction, occurring due to liberation of an inhibitor of plasminogen activator into circulation, was observed within 2-4 hrs after a single intravenous administration of rabbit interleukin-I into rats at a dose of 50 micrograms/kg, while the activator activity was increased in kidney heart, spleen and lung tissues. The similar data were obtained if the dose was either increased up to 150 micrograms/kg or decreased down to 5 micrograms/kg and 0.5 micrograms/kg, but the effect observed proved to be dose-dependent. Three injections of interleukin-I caused more pronounced increase in concentration of fibrinogen and antiplasmins as compared with controls.
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Reference: Liutova L.V., Andreenko G.V., Karabasova M.A., Rybakina E.G., Kozinets I.A., Ashmarin I.P., Interleukin-1 and fibrinolysis. In vivo studies, Voprosy meditsinskoi khimii, 1989, vol: 35(4), 75-78.
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