Voprosy meditsinskoi khimii (ISSN 0042-8809)

The status of the monooxygenase enzyme system of the liver in Salmonella infection in rats

   
Krakovskiĭ M.E., Ashirmetov A.Kh., Musabaev E.I., Alieva L.G.
PubMed Id: 2815687
Year: 1989 vol: 35  issue:4  pages: 89-91
Abstract: Content and activity of microsomal cytochromes P450 and b5, amidopyrine N-demethylase, aniline hydroxylase, NADPH cytochrome c reductase were studied in liver tissue of rats with salmonelliasis. Distinct inhibition of the liver monooxygenase enzymatic system was detected during the acute period of the disease; its normalization was complete within the reconvalescence period. Endotoxinemia appears to be mainly responsible for alterations in the microsomal enzymes activity observed.
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Reference: Krakovskiĭ M.E., Ashirmetov A.Kh., Musabaev E.I., Alieva L.G., The status of the monooxygenase enzyme system of the liver in Salmonella infection in rats, Voprosy meditsinskoi khimii, 1989, vol: 35(4), 89-91.
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