Voprosy meditsinskoi khimii (ISSN 0042-8809)

The role of cyclic nucleotides in reparative bone formation

   
Sveshnikov A.A., Ofitserova N.V., Ral'nikova S.V., Kuznetsov A.P.
PubMed Id: 2554593
Year: 1989 vol: 35  issue:4  pages: 9-11
Abstract: Distinct alterations in content of cyclic nucleotides were observed during treatment of 133 patients with fractures of long tubular bones. The following effects were found after initial increase in cAMP content: increase in tissue permeability, aseptic inflammation, inhibition of cell mitosis, acceleration of cell enzymes synthesis, of protein biosynthesis and of the rate of microcirculation in the traumatized region. Elevation of cGMP concentration led to initiation of bone marrow proliferation, to augmented formation of organic matrix and its mineralization. Monitoring of cyclic nucleotides concentration enabled to evaluate the reparative osteogenesis activity.
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Reference: Sveshnikov A.A., Ofitserova N.V., Ral'nikova S.V., Kuznetsov A.P., The role of cyclic nucleotides in reparative bone formation, Voprosy meditsinskoi khimii, 1989, vol: 35(4), 9-11.
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