Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of thymoptin on enzymatic fibrinolysis

   
Andreenko G.V., Ashmarin I.P., Zazhirei V.D., Livshits V.A., Serebriakova T.N., Podorol'skaia L.V.
PubMed Id: 2617925
Year: 1989 vol: 35  issue:5  pages: 108-111
Abstract: Stimulation of fibrinolysis, decrease in content of fibrinogen and inhibitors were observed after intravenous, intramuscular or subcutaneous administrations of thymoptine preparation (complex of peptides, isolated from mammalian thymus) at doses of 0.1 microgram, 1.0 microgram/200 g of rat body mass. A more long-term effect was found after a course of treatment involving 5 subcutaneous or intramuscular injections (1.0 microgram). Single intravenous administration of thymoptine (0.1 microgram/200 g) caused a moderate thrombolytic action. Development of thrombosis, provoked by subtotal dose of thrombin, was inhibited after subcutaneous injection of the preparation.
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Reference: Andreenko G.V., Ashmarin I.P., Zazhirei V.D., Livshits V.A., Serebriakova T.N., Podorol'skaia L.V., The effect of thymoptin on enzymatic fibrinolysis, Voprosy meditsinskoi khimii, 1989, vol: 35(5), 108-111.
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