Voprosy meditsinskoi khimii (ISSN 0042-8809)

Phospholipid-glycerides, cross-resistance of erythrocytes, malonic dialdehyde level and alpha-tocopherol levels in the plasma and erythrocytes of rats with alloxan diabetes before and after combined antioxidant therapy

   
Karagezian K.G., Gevorkian D.M.
PubMed Id: 2617931
Year: 1989 vol: 35  issue:5  pages: 27-30
Abstract: Quantitative and qualitative alterations in content of phospholipids were studied in erythrocytes of rats with alloxan diabetes: rate of lipid peroxidation and content of L-tocopherol were estimated in blood plasma before and after the antioxidant therapy. Patterns of lipid metabolism were normalized after the course of treatment involving simultaneous administration of L-tocopherol and ascorbic acid within 10-15 days. The antioxidants used decreased the rate of lipid peroxidation in erythrocyte membranes and stimulated biosynthesis of phospholipids de novo. Role of antioxidants in phospholipid metabolism is discussed.
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Reference: Karagezian K.G., Gevorkian D.M., Phospholipid-glycerides, cross-resistance of erythrocytes, malonic dialdehyde level and alpha-tocopherol levels in the plasma and erythrocytes of rats with alloxan diabetes before and after combined antioxidant therapy, Voprosy meditsinskoi khimii, 1989, vol: 35(5), 27-30.
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