Voprosy meditsinskoi khimii (ISSN 0042-8809)

Inhibitors of protein biosynthesis and development of dyslipoproteinemia in rabbits

   
Frol'kis V.V., Bogatskaia L.N., Novikova S.N.
PubMed Id: 2629238
Year: 1989 vol: 35  issue:6  pages: 23-27
Abstract: Acute alimentary hypercholesterolemia, developing after a single load with cholesterol, and experimental atherosclerosis, caused by long-term loading with cholesterol, were studied in young rabbits. Olivomycin, administered simultaneously with long-term cholesterol loading, and streptomycin, injected within 3 days before cholesterol loading, were used as inhibitors. These antibiotics prevented hypercholesterolemia, hyperlipoproteinemia and atherosclerosis development. The data obtained suggest that the drugs used inhibited development of atherosclerosis via selective blockade of apoB proteins synthesis in liver and intestinal tissues of the experimental animals.
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Reference: Frol'kis V.V., Bogatskaia L.N., Novikova S.N., Inhibitors of protein biosynthesis and development of dyslipoproteinemia in rabbits, Voprosy meditsinskoi khimii, 1989, vol: 35(6), 23-27.
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