Voprosy meditsinskoi khimii (ISSN 0042-8809)

Association of 3H-dexamethasone with cytoplasmic receptor proteins and their translocation into liver cell nuclei during aging

   
Fil'chenkov G.N.
PubMed Id: 2343574
Year: 1990 vol: 36  issue:1  pages: 42-45
Abstract: Interaction of 3H-dexamethasone with cytoplasmic proteins was studied in male rat liver cells. With ageing of the animals concentration of high affinity and low affinity glucocorticoid receptors was decreased 2-fold as well as the corresponding reduction of nuclear uptake in the steroid-receptor complexes was found. A protein species was found in cytoplasm of aged rat hepatocytes, which bound 3H-dexamethasone with 'extremely low' affinity and was not able to associate with the cell nuclei.
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Reference: Fil'chenkov G.N., Association of 3H-dexamethasone with cytoplasmic receptor proteins and their translocation into liver cell nuclei during aging, Voprosy meditsinskoi khimii, 1990, vol: 36(1), 42-45.
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