Voprosy meditsinskoi khimii (ISSN 0042-8809)

Synthesis of nucleic acids and dynamics of morphological indices of the granulation tissue of skin wounds in rats treated with 4-methyluracil

   
Silaeva S.A., Khatsernova B.Ya., Golenchenko V.A., Berchenko G.N., Nikolaev A.Ya., Shekhter A.B.
PubMed Id: 1693022
Year: 1990 vol: 36  issue:1  pages: 82-84
Abstract: Effect of 4-methyl uracil on dynamics of morphological patterns and the rate of nucleic acids synthesis was studied in granulation tissue developed during healing of full-layer skin wounds. Application of ointment containing 4-methyl uracil onto the wounds exhibited an antiinflammatory efficiency and decreased accumulation of leukocytes in the wound. The drug shortened the mitotic cycle in dividing fibroblasts, as a result of which periods of DNA synthesis became more frequent exhibiting two days duration. The rate of RNA synthesis was increased 1.5-2-fold. Content of acid glycosaminoglycans and collagen was increased in intercellular space surrounding fibroblasts.
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Reference: Silaeva S.A., Khatsernova B.Ya., Golenchenko V.A., Berchenko G.N., Nikolaev A.Ya., Shekhter A.B., Synthesis of nucleic acids and dynamics of morphological indices of the granulation tissue of skin wounds in rats treated with 4-methyluracil, Voprosy meditsinskoi khimii, 1990, vol: 36(1), 82-84.
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