Voprosy meditsinskoi khimii (ISSN 0042-8809)

Oxidative processes and phospholipid metabolism in hepatocyte membranes during alloxan diabetes

   
Karagezian K.G., Ovsepian L.M., Adonts K.G.
PubMed Id: 2363247
Year: 1990 vol: 36  issue:2  pages: 10-12
Abstract: Total content of phospholipids and their individual components were distinctly increased in microsomal, mitochondrial fractions and in inner mitochondrial membrane of rat hepatocytes under conditions of alloxan diabetes. The concentrations of these substances were decreased in outer mitochondrial membrane. Activation of lipid free-radical oxidation was found in all the membrane structures studied. In microsomal fraction of hepatocytes the rate of hydroxylation reaction was decreased, accompanied by a decrease in content of cytochromes b5 and P-450.
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Reference: Karagezian K.G., Ovsepian L.M., Adonts K.G., Oxidative processes and phospholipid metabolism in hepatocyte membranes during alloxan diabetes, Voprosy meditsinskoi khimii, 1990, vol: 36(2), 10-12.
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