Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of indomethacin on the activity of Na+,K+- and HCO3-atpases and prostaglandin levels in the rat ileum mucosa after exposure to cholera exotoxin

   
Dolmatova L.S.
PubMed Id: 2163563
Year: 1990 vol: 36  issue:2  pages: 18-19
Abstract: Preadministration of indomethacin (10 mg/kg of rat body mass), 1 hr before choleraic toxin injection, removed the toxin inhibitory effect on activity of Na+, K(+)-ATPase and decreased distinctly its inhibitory action on HCO3(-)-ATPase. At the same time, the indomethacin premedication caused a decrease in content of prostaglandins PGE, 6-keto-PGF1 alpha and of thromboxane B2 as compared with the choleraic toxin effect and controls. The data obtained corroborate the hypothesis on antisecretory effect of indomethacin occurring via PG-dependent mechanism.
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Reference: Dolmatova L.S., The effect of indomethacin on the activity of Na+,K+- and HCO3-atpases and prostaglandin levels in the rat ileum mucosa after exposure to cholera exotoxin, Voprosy meditsinskoi khimii, 1990, vol: 36(2), 18-19.
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