Voprosy meditsinskoi khimii (ISSN 0042-8809)

1-ethoxysilatrane: ulcerostatic effect and its possible mechanisms

   
Kuznetsov I.G., Rasulov M.M., Akabirov A.A., Suslova S.K., Voronkov M.G.
PubMed Id: 2363253
Year: 1990 vol: 36  issue:2  pages: 24-27
Abstract: Stimulating effect of I-ethoxy silatrane on healing of acetate derived stomach ulcer was studied in rats. The drug was shown to inhibit lipid peroxidation and free-radical oxidation in blood and gastric tissues as well as to accelerate reparation in ulcerous zone. I-Ethoxy silatrane interacted with artificial membranes and affected the respiration rate in liver mitochondria. Membranetropic effect of I-ethoxy silatrane appears to be involved in the drug ulcerostatic effect.
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Reference: Kuznetsov I.G., Rasulov M.M., Akabirov A.A., Suslova S.K., Voronkov M.G., 1-ethoxysilatrane: ulcerostatic effect and its possible mechanisms, Voprosy meditsinskoi khimii, 1990, vol: 36(2), 24-27.
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