Voprosy meditsinskoi khimii (ISSN 0042-8809)

Glycosylated lipoproteins as atherogenic factor in diabetes (review of the literature)

   
Denisenko T.V.
PubMed Id: 2194367
Year: 1990 vol: 36  issue:2  pages: 5-10
Abstract: Data on the role of glycosylated lipoproteins in atherogenesis are reviewed. Posttranslational modification of proteins involving nonenzymatic glycosylation occurred under conditions of normal state but the highest rate of these reactions was found in hyperglycemia (diabetes). Glycosylation, after blocking of the epsilon-amino group in lysyl residue in protein moiety of lipoproteins, transformed distinctly the physico-chemical and metabolic properties of apoproteins, as a result of which normal catabolism of lipoproteins was impaired. Reactions of glycosylation are mainly responsible for pathogenetic interrelationship between diabetes and atherosclerosis. Glycosylation of lipoproteins may contribute to development of atherosclerosis via autoimmunity mechanisms.
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Reference: Denisenko T.V., Glycosylated lipoproteins as atherogenic factor in diabetes (review of the literature), Voprosy meditsinskoi khimii, 1990, vol: 36(2), 5-10.
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