Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of thymosin and dietary factors on the phospholipid composition and intensity of lipid peroxidation in the liver, spleen, bone marrow, and lymphocytes of thymectomized rats

   
Mamutov Zh.I.
PubMed Id: 2363262
Year: 1990 vol: 36  issue:2  pages: 61-65
Abstract: Influence of thymosin and alimentary factors on phospholipid composition and the rate of peroxidation in liver including subcellular organelles), spleen, bone marrow and lymphocytes of thymectomized rats was studied within different periods after the operation (40, 70, 100, 190 and 370 days). Phospholipid composition and POL intensity in the tissues, subcellular structures and cells studied were markedly changed as a result of the immunodeficiency developed, especially within later periods after thymectomy. Content of phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol and the rate of spontaneous POL were decreased while lysophosphatidyl choline, cardiolipin, phosphatidic acid and the rate of ascorbate-induced POL were increased. Administration of thymosin normalized completely the phospholipid fractions studied and lipid peroxidation in all the preparations studied within the early periods after thymectomy as well as the same effect was observed within the later periods when the drug was administered simultaneously with vitamins A and E; these alimentary factors improved complete normalization of the patterns studied.
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Reference: Mamutov Zh.I., The effect of thymosin and dietary factors on the phospholipid composition and intensity of lipid peroxidation in the liver, spleen, bone marrow, and lymphocytes of thymectomized rats, Voprosy meditsinskoi khimii, 1990, vol: 36(2), 61-65.
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