Voprosy meditsinskoi khimii (ISSN 0042-8809)

Indirect electrochemical oxidation using active oxygen carriers in a model of detoxicating function of the liver

   
Sergienko V.I., Martynov A.K., Vasil'ev Yu.B., Grinberg V.A., Shilov V.N., Bulygina T.V.
PubMed Id: 2382422
Year: 1990 vol: 36  issue:3  pages: 28-32
Abstract: As development of the electrochemical model of liver tissue monooxygenase system met with a serious problem of compatibility between electrochemical unit and blood, a procedure of indirect electrochemical oxidation of blood was proposed where carriers of active oxygen were used. Blood did not contact with the electrochemical system and electrolysis occurred in solution of oxygen carrier (0.89% NaCl), which accumulated active oxygen in the form of sodium hypochlorite. Sodium hypochlorite, administered into patients, enabled to bypass "the effect of protein protection" of toxic metabolites; it simulated both liver tissue monooxygenase functions and phagocytosis molecular mechanisms.
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Reference: Sergienko V.I., Martynov A.K., Vasil'ev Yu.B., Grinberg V.A., Shilov V.N., Bulygina T.V., Indirect electrochemical oxidation using active oxygen carriers in a model of detoxicating function of the liver, Voprosy meditsinskoi khimii, 1990, vol: 36(3), 28-32.
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