Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of cardioactive drugs on the proteolytic activity of the rat heart muscle

   
Karapetian R.G., Akopian T.N., Oganisian A.I., Oganesian S.S.
PubMed Id: 1974373
Year: 1990 vol: 36  issue:3  pages: 54-57
Abstract: Cardioactive drugs--beta-adrenoblocking agents (propranolol, trasicor and cordanum) and Ca2(+)-antagonists (nifedipine and phenoptine)--exhibited both activating and inhibitory effects on proteolytic activity in rat heart tissue extract. The beta-adrenoblocking agents did not affect distinctly the activity of partially purified cathepsin D and Ca2(+)-dependent neutral protease from myocardium. Nifedipine inhibited cathepsin D by 50% and Ca2(+-dependent neutral protease--by 75%; phenoptine inhibited also the latter enzyme by 30%.
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Reference: Karapetian R.G., Akopian T.N., Oganisian A.I., Oganesian S.S., The effect of cardioactive drugs on the proteolytic activity of the rat heart muscle, Voprosy meditsinskoi khimii, 1990, vol: 36(3), 54-57.
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