Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of progesterone on metabolism of cholesterol esters in macrophages cultured with acetylated low density lipoproteins

   
Dolgov A.V., Dushkin M.I., Mandrikova E.V.
PubMed Id: 2238531
Year: 1990 vol: 36  issue:4  pages: 38-41
Abstract: Effect of progesterone on esterification of free cholesterol, on content of free cholesterol and its esters was studied in rat macrophages, cultivated in presence of acetyl-derivatives of low density lipoproteins (Ac-LDL), as well as on mobilization of cholesterol from macrophages. Progesterone at a dose of 0.5-10 micrograms per I ml of cultivating medium caused dose-dependent inhibition of I-14C-oleate incorporation into cholesterol esters of macrophages cultivated with Ac-LDL (50 micrograms of protein/ml). In the medium free of LDL progesterone caused an increase of cholesterol in macrophages by 45%, while addition of 100 micrograms/ml LDL led to a decrease of free cholesterol by 20% of the initial level. If macrophages pre-enriched with 4-C14-cholesterol were cultivated in LDL containing medium, progesterone increased the 4-14C-cholesterol liberation into medium and decreased the cholesterol content in macrophages. Under conditions of macrophages incubation in the LDL-free medium, progesterone increased the free cholesterol content in these cells but did not affect the 4-14C-cholesterol liberation into medium. The data obtained suggest that the progesterone-induced inhibition of free cholesterol esterification may increase its mobilization from macrophages only if the LDL acceptor function is unaltered.
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Reference: Dolgov A.V., Dushkin M.I., Mandrikova E.V., The effect of progesterone on metabolism of cholesterol esters in macrophages cultured with acetylated low density lipoproteins, Voprosy meditsinskoi khimii, 1990, vol: 36(4), 38-41.
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