Voprosy meditsinskoi khimii (ISSN 0042-8809)

Lysosomal hydrolases of various rat organs in the process of cell nutrition

   
Vasil'ev A.V., Bregvadze N.S., Tutel'ian V.A.
PubMed Id: 2238532
Year: 1990 vol: 36  issue:4  pages: 45-47
Abstract: Activity of lysosomal proteinases cathepsins A, B, C, D, H and L was studied in liver, kidney, spleen, thymus, heart, skeletal muscle and brain tissues of rats, maintained on full value diet, on a diet free of proteins and on the diet enriched with methionine. Distinctly dissimilar reactions of thiol-dependent proteinases was detected in liver, heart tissues and skeletal muscles as compared with the reaction of cathepsins A and D; activity of cathepsins B, H and L was decreased 1.5-2-fold in the animal groups maintained on diets both free of proteins and enriched with methionine. The data obtained suggest that concentration of endogenous inhibitors of lysosomal thiol-dependent proteinases rather than content of SH-groups in tissues was responsible for alterations of their activity under conditions of protein starvation.
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Reference: Vasil'ev A.V., Bregvadze N.S., Tutel'ian V.A., Lysosomal hydrolases of various rat organs in the process of cell nutrition, Voprosy meditsinskoi khimii, 1990, vol: 36(4), 45-47.
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