Voprosy meditsinskoi khimii (ISSN 0042-8809)

Inhibition of the angiotensin-converting enzyme from bovine kidney by organophosphorus analogs of amino acids

   
Shumiantseva V.V., Gandurina I.A., Osipova T.I., Kugaevskaia E.V.
PubMed Id: 2238538
Year: 1990 vol: 36  issue:4  pages: 74-76
Abstract: Reactions of amino acid phosphoorganic derivatives with angiotensin-converting enzyme (dipeptidyl carboxypeptidase) were studied. Substitution of the amino acid carboxyl group by HS- or P(O) (OH)2-groups did not cause the enzyme considerable inhibition. The enzymatic activity was inhibited by 20-50% in presence of 1 X 10(-3) M Asp, Met and Cys phosphoorganic derivatives. These amino acid derivatives may be used as potential antihypertensive drugs because of their metabolic stability and inhibitory action on the enzyme.
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Reference: Shumiantseva V.V., Gandurina I.A., Osipova T.I., Kugaevskaia E.V., Inhibition of the angiotensin-converting enzyme from bovine kidney by organophosphorus analogs of amino acids, Voprosy meditsinskoi khimii, 1990, vol: 36(4), 74-76.
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