Voprosy meditsinskoi khimii (ISSN 0042-8809)

Protective effect of selenium in acute T-2 mycotoxicosis

   
Kravchenko L.V., Kuz'mina E.E., Avren'eva L.I., Tutel'ian V.A.
PubMed Id: 2251789
Year: 1990 vol: 36  issue:5  pages: 36-38
Abstract: Male Wistar rats were fed diets supplemented with selenium (0.5 and 2.5 mg/kg) for 6 weeks. When T-2 toxin was administered at 3.8 mg/kg body weight; sings of intoxication were less distinct in rats fed selenium-supplemented diets. Mortality caused by T-2 toxin was two times lower if selenium content amounted to 2.5 mg/kg. The level of cytochrome P-450 and the rate of deethylation of 7-ethoxycoumarin were considerably decreased in the liver of rats that received T-2 toxin and fed a diet with high selenium content. At the same time the activity of epoxide hydrolase and UDP-glucuronosyltransferase was significantly higher (1.6 and 1.7 times more) as compared with unsupplemented group. The results obtained allow to assume that there is a relationship between the decrease of T-2 toxin toxicity and the change in its metabolism in rats fed selenium-supplemented diets.
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Reference: Kravchenko L.V., Kuz'mina E.E., Avren'eva L.I., Tutel'ian V.A., Protective effect of selenium in acute T-2 mycotoxicosis, Voprosy meditsinskoi khimii, 1990, vol: 36(5), 36-38.
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