Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of adenosine on the distribution of glucocorticoid receptor complexes in rat thymocytes

   
Dukhanin A.S.
PubMed Id: 2251803
Year: 1990 vol: 36  issue:5  pages: 81-83
Abstract: In presence of adenosine (10(-7)-10(-6) M) content of nuclear 3H-hydrocortisone-receptor complexes was increased in rat thymus lymphocytes, while amount of these complexes was decreased in cytosol of these cells. DEAE-cellulose chromatography of the 3H-hydrocortisone-receptor complexes demonstrated that adenosine 1.10(-6) M altered the ratio between active and non-active forms of the hormone-receptor complex. Adenosine appears to regulate transformation and translocation of the glucocorticoid-receptor complexes into the cell-target nuclei cAMP-dependent apparatus.
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Reference: Dukhanin A.S., The effect of adenosine on the distribution of glucocorticoid receptor complexes in rat thymocytes, Voprosy meditsinskoi khimii, 1990, vol: 36(5), 81-83.
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