Voprosy meditsinskoi khimii (ISSN 0042-8809)

Lysosomes and lipoprotein metabolism in the liver

Panin L.E.
PubMed Id: 2075714
Year: 1990 vol: 36  issue:6  pages: 2-4
Abstract: Apoproteins were not hydrolyzed completely in liver cells after internalization of lipoproteins. They were accumulated in secondary lysosomes as a result of lipoprotein disintegration and reacted actively with lysosomal membranes, thus inducing pore-formation in the structures. Under these conditions lysosomal enzymes were not liberated into the environmental medium, while contact with the corresponding substrates was increased. Small molecular mass enabled the apoproteins to penetrate into cell cytoplasm, where they could interact with all the cytostructures: nuclei, mitochondria, microsomes and cytosol, carrying out their coenzyme properties.
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Reference: Panin L.E., Lysosomes and lipoprotein metabolism in the liver, Voprosy meditsinskoi khimii, 1990, vol: 36(6), 2-4.