Voprosy meditsinskoi khimii (ISSN 0042-8809)

Structure-activity status of the rat liver lysosomal apparatus upon the action of dithiocarbamate pesticides

   
Shubitidze T.M., Busova T.N., Riazanova R.A., Tabagari S.I.
PubMed Id: 2075716
Year: 1990 vol: 36  issue:6  pages: 24-26
Abstract: Total and non-sedimentable activity of cathepsins A, B, C and D in rat liver tissue as well as activity of these lysosomal proteinases in blood serum were studied during intragastric administration of tetramethyl thiuramdisulfide (TMTD), polymartsine and tsineb within 30 days at a dose of 1/20 LD50. The enzymatic activity alterations, which involved a decrease in total activity of lysosomal proteinases and an increase of the activity in non-sedimentable fraction and blood serum, were distinctly decreased in series: TMTD--polymartsine--tsineb. The data obtained suggest that structure-functional state of lysosomes was considerably altered in response to the effect of dithiocarbamate-containing pesticides.
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Reference: Shubitidze T.M., Busova T.N., Riazanova R.A., Tabagari S.I., Structure-activity status of the rat liver lysosomal apparatus upon the action of dithiocarbamate pesticides, Voprosy meditsinskoi khimii, 1990, vol: 36(6), 24-26.
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