Voprosy meditsinskoi khimii (ISSN 0042-8809)

Activity of alkaline phospholipase A in lysosomes and mitochondria in damaged rabbit myocardium

   
Efimova L.V.
PubMed Id: 2075719
Year: 1990 vol: 36  issue:6  pages: 34-36
Abstract: Alkaline phospholipases A were studied in rabbit myocardium under normal conditions and in heart impairment of various etiology. In mitochondrial fraction activity of phospholipase A was increased with elevation of Ca2+ concentration, while the enzyme was Ca2(+)-independent in lysosomes. Hemodynamic overloading of heart, acute local myocardial ischemia and diphtheritic intoxication led to an increase (2-4-fold) of mitochondrial phospholipases A activity with simultaneous decrease of the enzymatic activity in lysosomal membranes.
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Reference: Efimova L.V., Activity of alkaline phospholipase A in lysosomes and mitochondria in damaged rabbit myocardium, Voprosy meditsinskoi khimii, 1990, vol: 36(6), 34-36.
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