Voprosy meditsinskoi khimii (ISSN 0042-8809)

Prevention of cAMP stimulation of activity of various oxidative mitochondrial enzymes with lidocaine and aminazine

   
Medvedev A.E.
PubMed Id: 1963720
Year: 1990 vol: 36  issue:6  pages: 74-76
Abstract: Lidocaine or aminazine (chlorpromazine) injected to rats or incubated with liver mitochondria prevented NAD-isocitrate dehydrogenase and transhydrogenase activation during the subsequent incubation of mitochondria with cAMP. Integrity of mitochondrial membranes is obligatory for manifestation of the drugs effect. Lidocaine and aminazine-induced desensitization of mitochondria to the cAMP action was apparently realized via alteration in the state (and/or composition) of lipid component of mitochondria. The significance of mitochondria sensitivity to cAMP stimulation is discussed.
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Reference: Medvedev A.E., Prevention of cAMP stimulation of activity of various oxidative mitochondrial enzymes with lidocaine and aminazine, Voprosy meditsinskoi khimii, 1990, vol: 36(6), 74-76.
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