Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of gamma-hydroxybutyric acid on the reaction rate of phosphate-containing metabolites in the rat brain during ischemia estimated from (31)P-NMR spectroscopic data

   
Likhova St.S., Likhodii S.St., Sibel'dina L.A.
PubMed Id: 1858332
Year: 1991 vol: 37  issue:1  pages: 19-21
Abstract: Protective effects of gamma-hydroxybutyric acid on bioenergetic reactions were studied in brain of rats with ischemia using 31P-NMR spectroscopy in vivo. Intraperitoneal preadministration of gamma-hydroxybutyric acid at a dose of 400 mg/kg within 30-40 min before ischemia led to a decrease in the ATP pool in ischemic brain tissue, to alteration in the PCr/ATP ratio in the 31P-NMR spectrum, to prevention of Pi concentration increase and to increase in the intracellular acidosis development rate. Possible mechanisms of the gamma-hydroxybutyric acid effects on bioenergetic reactions in nervous tissue during ischemia are discussed.
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Reference: Likhova St.S., Likhodii S.St., Sibel'dina L.A., The effect of gamma-hydroxybutyric acid on the reaction rate of phosphate-containing metabolites in the rat brain during ischemia estimated from (31)P-NMR spectroscopic data, Voprosy meditsinskoi khimii, 1991, vol: 37(1), 19-21.
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