Voprosy meditsinskoi khimii (ISSN 0042-8809)

Biotransformation and toxicity of xenobiotics in various routes of administration of vitamin A into the rat body

   
Pentiuk A.A., Gutsol V.I., Bogdanov N.G.
PubMed Id: 1858338
Year: 1991 vol: 37  issue:1  pages: 36-38
Abstract: Deficiency of vitamin A in rats caused a decrease in metabolic rate of acetanilide as well as in elimination of voltaren from blood plasma, while excess of the vitamin (3,000 IU/kg) stimulated voltaren elimination and increased excretion with urine of aminophenol conjugates of acetanilide with sulfuric and glucuronic acids. Under conditions of vitamin A deficiency formation of acetanilide toxic metabolites was increased as a result of which excretion of mercapturic acids with urine was elevated but excess of vitamin A and its hyperdose inhibited these reactions. At the same time, deficiency of vitamin A amplified the paracetamol and voltaren toxicity and its excess exhibited protective effects.
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Reference: Pentiuk A.A., Gutsol V.I., Bogdanov N.G., Biotransformation and toxicity of xenobiotics in various routes of administration of vitamin A into the rat body, Voprosy meditsinskoi khimii, 1991, vol: 37(1), 36-38.
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