Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in kinetics of deaminated biogenic amines in spontaneous hypertension

   
Ioffina D.I., Smirnov I.E., Gorkin V.Z.
PubMed Id: 1858344
Year: 1991 vol: 37  issue:1  pages: 59-63
Abstract: Rate of serotonin and benzylamine deamination was increased in liver tissue of rats with spontaneous hypertension. The increase was due to elevation in Vmax value for monoamine oxidases of the A and B types as compared with the corresponding values of control animals. The Vmax value was increased in kidney of hypertensive animals for MAO of the B type (benzylamine as a substrate). At the same time, Km for MAO of the B type was increased in liver tissue, while Km for MAO of the A type was decreased in brain of hypertensive animals. Titration of the MAO active sites exhibited their increased concentration in the B type MAO in liver mitochondria of experimental animals. The data obtained suggest an important role of alterations in the MAO catalytic activity in pathogenesis of spontaneous hypertension.
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Reference: Ioffina D.I., Smirnov I.E., Gorkin V.Z., Changes in kinetics of deaminated biogenic amines in spontaneous hypertension, Voprosy meditsinskoi khimii, 1991, vol: 37(1), 59-63.
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