Voprosy meditsinskoi khimii (ISSN 0042-8809)

Study of the effect of an inhibitor of carnitine-dependent metabolism of mildronate on the oxidation of fatty acids in the liver mitochondria of intact rats

   
Kagan T.I., Simkhovich B.Z., Kalvinsh I.Ya., Lukevits E.Ya.
PubMed Id: 1897193
Year: 1991 vol: 37  issue:2  pages: 44-46
Abstract: Effect af antiischemic drug mildronate 3-(2,2,2-trimethylhydrazinium) propionate on oxidation of sodium octanoate and L-palmitoyl carnitine was studied in liver mitochondria of intact rats using polarographic procedure. After 10 days of administration of mildronate at a dose of 200 mg/kg per os oxidation of sodium octanoate was stimulated in liver mitochondria while the rate of L-palmitoyl carnitine oxidation was unaltered. The data obtained suggest that mildronate stimulated the carnitine-independent fatty acid oxidation which appears to occur as a compensation for inhibition of the carnitine-dependent oxidation by the drug.
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Reference: Kagan T.I., Simkhovich B.Z., Kalvinsh I.Ya., Lukevits E.Ya., Study of the effect of an inhibitor of carnitine-dependent metabolism of mildronate on the oxidation of fatty acids in the liver mitochondria of intact rats, Voprosy meditsinskoi khimii, 1991, vol: 37(2), 44-46.
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