Voprosy meditsinskoi khimii (ISSN 0042-8809)

Change in the catalytic properties of mitochondrial monoamine oxidase in experimental audiogenic epilepsy

   
Raĭgorodskaia D.I., Medvedev A.E., Gorkin V.Z., Fedotova I.B., Semiokhina A.F.
PubMed Id: 1897194
Year: 1991 vol: 37  issue:2  pages: 46-48
Abstract: Catalytic properties of mitochondrial monoamine oxidases (MAO) were studied in brain, heart, liver and kidney of rats of Krushinskii-Molodkina strain with inherited audiogenic epilepsia. In brain of these rats a. 2.5-fold decrease of Vmax of serotonin (MAO-A substrate) deamination has been found. During audiogenic epileptiformic attack 2.5-5-fold decrease of Vmax of serotonin deamination in brain and liver and also decrease of benzylamine (MAO-B substrate) oxidation in brain were found. Simultaneously oxidation of glucosamine and gamma-aminobutyric acid was markedly increased (up to 5-fold and more) in brain. The data obtained showed that qualitative transformation occurred in catalytic properties of MAO which may be an important pathogenic factor in the development of epileptiformic attack.
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Reference: Raĭgorodskaia D.I., Medvedev A.E., Gorkin V.Z., Fedotova I.B., Semiokhina A.F., Change in the catalytic properties of mitochondrial monoamine oxidase in experimental audiogenic epilepsy, Voprosy meditsinskoi khimii, 1991, vol: 37(2), 46-48.
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