Voprosy meditsinskoi khimii (ISSN 0042-8809)

Selective inhibition of monoamine oxidase in bovine brain by befol and moclobemide

   
Moskvitina T.A., Gankina E.M., Val'dman A.V.
PubMed Id: 1897195
Year: 1991 vol: 37  issue:2  pages: 49-51
Abstract: Effects of befol and moklobemide on thyramine-, serotonin- and 2-phenyl ethylamine deaminase activities of mitochondrial monoamine oxidase from bovine truncus cerebri were studied. These drugs are reversible noncompetitive inhibitors of the enzyme not requiring preincubation. They inhibited most effectively the serotonin deaminase activity as compared with phenyl ethylamine deaminase activity, however they should not be concerned with typical inhibitors of monoamine oxidases of the A type as inhibition of thyramine deaminase activity was not found.
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Reference: Moskvitina T.A., Gankina E.M., Val'dman A.V., Selective inhibition of monoamine oxidase in bovine brain by befol and moclobemide, Voprosy meditsinskoi khimii, 1991, vol: 37(2), 49-51.
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