Voprosy meditsinskoi khimii (ISSN 0042-8809)

The negative effect of enkephalins on kidney energetics in rats with hemorrhages

   
Slepushkin V.D., Grässler Y., Scheuch D.W.
PubMed Id: 1654673
Year: 1991 vol: 37  issue:2  pages: 51-53
Abstract: Content of adenine nucleotides, lactic and pyruvic acids, glucose and fructose-6-phosphate was studied in kidney of rats with hemorrhage constituting 3% of body mass after intravenous administration at a dose of 100 mg/kg of agonists of mu-opiate receptors DAGO and delta-opiate receptors DADL and dalargin. Stimulation of both these types of receptors amplifies the kidney ischemia developed after hemorrhage, which was expressed as increased decomposition of ATP, decrease in energetic charge of the adenine nucleotide system (DAGO) and increase in content of AMP (DADL, dalargin).
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Reference: Slepushkin V.D., Grässler Y., Scheuch D.W., The negative effect of enkephalins on kidney energetics in rats with hemorrhages, Voprosy meditsinskoi khimii, 1991, vol: 37(2), 51-53.
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