Voprosy meditsinskoi khimii (ISSN 0042-8809)

Detection and identification of new cardioactive proteins in cattle heart

   
Popova T.V., Srapionian R.M., Galoian A.A.
PubMed Id: 1897197
Year: 1991 vol: 37  issue:2  pages: 56-58
Abstract: Seven cardioactive polypeptides were identified in precardiac and auricular regions of bovine heart. Procedures used for purification of the polypeptides involved extraction of water-soluble proteins, fractionation by ammonium sulfate, gel filtration on Sephadex G-100, chromatography and rechromatography on DEAE cellulose. Some physico-chemical and biological properties were studied; amino acid composition, N-terminal amino acids, molecular mass and the effects on coronary blood vessels. The data obtained suggest that multiple forms of these proteins may exist either as a result of partial hydrolysis of large molecules or due to processing of precursors.
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Reference: Popova T.V., Srapionian R.M., Galoian A.A., Detection and identification of new cardioactive proteins in cattle heart, Voprosy meditsinskoi khimii, 1991, vol: 37(2), 56-58.
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