Voprosy meditsinskoi khimii (ISSN 0042-8809)

Excretion of pyridinoline with urine in children with Ehlers-Danlos syndrome and Marfan's syndrome and the effect of beta blocker and complex vitamin therapy on it

   
Prozorovskaia N.N., Kozlov E.A., Luk'ianov S.V., Rudakov S.S., Prozorovskii V.N., Del'vig A.A.
PubMed Id: 1680259
Year: 1991 vol: 37  issue:2  pages: 66-69
Abstract: Excretion of pyridinoline and polypeptide-bound hydroxyproline with urine was studied in 27 children with hereditary impairment of connective tissue. At the same time, effects of beta-adrenoblocking agents and vitamin complex, prescribed during preoperation period before thoracoplasty in hereditary chest deformation, were investigated. Clinical efficiency of the treatment depended distinctly on the initial value of ratios pyridinoline/creatinine and polypeptide-bound hydroxyproline/creatinine. Total positive effect of the therapeutic course, considering also echocardiographic examination and postoperational complications, was observed in 44% of patients with Ehlers-Dunlop syndrome and in 75% of patients with Marfan syndrome
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Reference: Prozorovskaia N.N., Kozlov E.A., Luk'ianov S.V., Rudakov S.S., Prozorovskii V.N., Del'vig A.A., Excretion of pyridinoline with urine in children with Ehlers-Danlos syndrome and Marfan's syndrome and the effect of beta blocker and complex vitamin therapy on it, Voprosy meditsinskoi khimii, 1991, vol: 37(2), 66-69.
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