Voprosy meditsinskoi khimii (ISSN 0042-8809)

Dynamics of the activity of cytochrome oxidase and glutathione level in tissues of rats, poisoned with potassium cyanides and nitriles

   
Kutsenko S.A., Shilov V.V.
PubMed Id: 1654675
Year: 1991 vol: 37  issue:2  pages: 72-74
Abstract: Rats were intoxicated with LD50 of potassium cyanide and some nitriles. Content of glutathione in brain and liver tissues and activity of cytochrome oxidase in brain were studied. Activity of brain cytochrome oxidase was inhibited in rats intoxicated with cyanide, acrylonitrile and valeronitrile. All the nitriles studied reduced the tissue glutathione content. Cyanides did not exhibit any effects on glutathione concentration.
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Reference: Kutsenko S.A., Shilov V.V., Dynamics of the activity of cytochrome oxidase and glutathione level in tissues of rats, poisoned with potassium cyanides and nitriles, Voprosy meditsinskoi khimii, 1991, vol: 37(2), 72-74.
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