Voprosy meditsinskoi khimii (ISSN 0042-8809)

Pharmacokinetics of human milk lactoferrin in intact mice and tumor-carrying animals

   
Kazachkina N.I., Nemtsova E.R., Iakubovskaia R.I., Karmakova T.A., Ivanova L.M., Sokolov A.V.
PubMed Id: 1949681
Year: 1991 vol: 37  issue:3  pages: 35-37
Abstract: Pharmacokinetics of iodine containing and native lactoferrin from human milk was studied in intact mice and the animals with Ehrlich ascites carcinoma. Both these antigens, native and I-lactoferrin, were similarly distributed in intact mice body. The same pharmacokinetics was found in tumor-bearing animals. Exogenous lactoferrin penetrated mainly into liver tissue, then simultaneously with bile--into small intestine and further into large intestine. Distinct accumulation of the glycoprotein was not found in tumor tissue.
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Reference: Kazachkina N.I., Nemtsova E.R., Iakubovskaia R.I., Karmakova T.A., Ivanova L.M., Sokolov A.V., Pharmacokinetics of human milk lactoferrin in intact mice and tumor-carrying animals, Voprosy meditsinskoi khimii, 1991, vol: 37(3), 35-37.
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