Voprosy meditsinskoi khimii (ISSN 0042-8809)

Brain monoamine oxidase during aging

   
Voĭtenko N.N., Popova N.K.
PubMed Id: 1750205
Year: 1991 vol: 37  issue:4  pages: 28-31
Abstract: MAO activities were studied in 4 months old and 19 months old Wistar rats. MAO-B activity was higher in brain stem and hemispheres of old rats as compared with that of young animals. MAO-A activity was lowered only in the stem and was not changed in the hemispheres of old rats. Actinomycin D increased MAO-A activity in the brain stem of young rats and lowered MAO-B activity in the hemispheres of old rats. Emotional stress increased MAO-A activity in the stem and hemispheres of both young and old animals. Actinomycin D abolished the stress effect on these two forms of MAO both young and old rats. Delta-sleep including peptide at the dose of 120 micrograms/100 g increased MAO-A activity and lowered MAO-B activity in young animals but did not affect the MAO-A activity in old rats.
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Reference: Voĭtenko N.N., Popova N.K., Brain monoamine oxidase during aging, Voprosy meditsinskoi khimii, 1991, vol: 37(4), 28-31.
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