Voprosy meditsinskoi khimii (ISSN 0042-8809)

Level and ratio of prostaglandins group E and F2(alpha) in bronchoalveolar washes in pulmonary tuberculosis patients

   
Kaminskaia G.O., Blonskaia G.Yu., Omarov T.O., Lovacheva O.V.
PubMed Id: 1750216
Year: 1991 vol: 37  issue:4  pages: 71-73
Abstract: Content of prostaglandins PGE and PGF2 alpha was studied by means of radioimmunoassay; their ratio was calculated in bronchoalveolar lavages obtained from impaired lung and from contralateral, intact lung of 86 patients with various forms of pulmonary tuberculosis. Concentration of prostaglandins was calculated per 1 mg of protein in lavage to standardize the data obtained. In the patients with tuberculosis production of PGE was increased in both lungs. However, the prostaglandin content was distinctly higher in the impaired lung but approximately similar in various forms of the disease. Hyperproduction of PGF2 alpha occurred in the impaired lung and depended on the type of the process. Content of PGF2 alpha was maximal in complicated destructive forms of tuberculosis. Bronchial muscle tension depended on the ratio of both groups of prostaglandins in bronchoalveolar space. Bronchial obstruction was accompanied by a decrease of PGE content in intact lung and by high concentration of PGF2 alpha near the tuberculosis focus.
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Reference: Kaminskaia G.O., Blonskaia G.Yu., Omarov T.O., Lovacheva O.V., Level and ratio of prostaglandins group E and F2(alpha) in bronchoalveolar washes in pulmonary tuberculosis patients, Voprosy meditsinskoi khimii, 1991, vol: 37(4), 71-73.
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