Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of actinomycin D on lysosomal proteinase activity in murine macrophages and spleen during immune response

   
Vasil'ev A.V., Vorobeichik T.A., Gutkin D.V., Levitskaia A.B., Tutel'ian V.A.
PubMed Id: 1759394
Year: 1991 vol: 37  issue:5  pages: 33-35
Abstract: Actinomycin D inhibited activation of lysosomal cathepsins A, B, C, D, H and L in peritoneal macrophages, caused by T-dependent antigen (sheep erythrocytes), of mice CBA X C57BL/6 strain. At the same time, the antibiotic stimulated activity of cathepsins A, C, D and H but decreased content of antibody-producing cells in spleen tissue. Inhibition of lysosomal proteinases in macrophages may be responsible for immunodepressive effect of actinomycin D.
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Reference: Vasil'ev A.V., Vorobeichik T.A., Gutkin D.V., Levitskaia A.B., Tutel'ian V.A., The effect of actinomycin D on lysosomal proteinase activity in murine macrophages and spleen during immune response, Voprosy meditsinskoi khimii, 1991, vol: 37(5), 33-35.
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