Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of ceruloplasmin conformation on its activity: significance for clinical analysis

   
Taras'ev M.Iu., Saburenkova E.P., Dantsig I.I., Moshkov K.A., Ryl'kov V.V.
PubMed Id: 1661974
Year: 1991 vol: 37  issue:5  pages: 43-46
Abstract: Conformational properties of ceruloplasmin were studied immediately in blood serum of healthy volunteers, patients with tuberculosis, with pulmonary cancer, with pneumonia and with Wilson-Konovalov disease. The glycoprotein conformation was found to depend on the volunteer physiological state and/or available pathology. The ceruloplasmin conformation and status of its copper-containing sites of the I type affected the enzyme oxidase properties and hence routine colorimetric procedures require some corrections for estimation of ceruloplasmin concentration and activity in blood serum.
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Reference: Taras'ev M.Iu., Saburenkova E.P., Dantsig I.I., Moshkov K.A., Ryl'kov V.V., Effect of ceruloplasmin conformation on its activity: significance for clinical analysis, Voprosy meditsinskoi khimii, 1991, vol: 37(5), 43-46.
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