Voprosy meditsinskoi khimii (ISSN 0042-8809)

Isolation and characteristics of fibronectin from fibrinolytically active human plasma

   
Litvinov R.I., Khvatov V.B., Shakirov K.T., Abdullin A.R., Solov'eva I.Z.
PubMed Id: 1759396
Year: 1991 vol: 37  issue:5  pages: 47-49
Abstract: Properties of fibronectin, isolated by means of affinity chromatography from blood plasma of suddenly dead persons, were studied. This blood exhibited high fibrinolytic potential and was not capable of clotting due to degradation of fibrinogen. At the same time, fibronectin was also isolated from blood plasma of healthy volunteers. Properties of these fibronectins of dissimilar origin were studied using the following parameters: content of immunoreactive and bioreactive fibronectin in blood plasma, affinity towards gelatin, yield of fibronectin from blood plasma, molecular mass, heterogeneity. Both these fibronectins from different sources of blood plasma were similar in their properties studied, thus demonstrating that any significant degradation of fibronectin did not occur in hyperfibrinolysis in vivo.
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Reference: Litvinov R.I., Khvatov V.B., Shakirov K.T., Abdullin A.R., Solov'eva I.Z., Isolation and characteristics of fibronectin from fibrinolytically active human plasma, Voprosy meditsinskoi khimii, 1991, vol: 37(5), 47-49.
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