Voprosy meditsinskoi khimii (ISSN 0042-8809)

Use of chloral hydrate for assessing the detoxifying function of the liver in experimental pathology

   
Riabinin V.E., Lifshits R.I.
PubMed Id: 1759398
Year: 1991 vol: 37  issue:5  pages: 52-53
Abstract: A new procedure, developed for evaluation of the liver tissue detoxicating activity in experimental pathology, involved estimation of chloral hydrate pharmacological efficiency and registration of animal sleep duration. As activity of uridine phosphate glucuronyl transferase, the key enzyme of the second step of biotransformation, was found to be inhibited after thermic burns, treatment of the disease using phenobarbital appears to correct the enzymatic activity.
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Reference: Riabinin V.E., Lifshits R.I., Use of chloral hydrate for assessing the detoxifying function of the liver in experimental pathology, Voprosy meditsinskoi khimii, 1991, vol: 37(5), 52-53.
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