Voprosy meditsinskoi khimii (ISSN 0042-8809)

Rapid time-resolved fluoroimmunometric analysis of myoglobin

   
Gracheva E.A., Nechaeva M.V., Roshke V.V., Rykova E.Yu., Shishkin G.V., Bredikhin A.V.
PubMed Id: 1759412
Year: 1991 vol: 37  issue:5  pages: 89-92
Abstract: High performance quantitative procedure for evaluation of myoglobin in blood serum is developed. The principle of two-site immunometry was used involving monoclonal antibodies against nonoverlapping epitopes of myoglobin molecule. The fluorescent compound containing europium served as a label of the antibody. Modification of the single-step assay enabled to increase the velocity of the assay to about 30 min and simplify it. The assay allowed estimation of myoglobin over a broad range of concentrations from 2 ng up to 1,000 ng/ml. The assay may be recommended for use in clinical practice for express diagnosis of myocardium infarction.
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Reference: Gracheva E.A., Nechaeva M.V., Roshke V.V., Rykova E.Yu., Shishkin G.V., Bredikhin A.V., Rapid time-resolved fluoroimmunometric analysis of myoglobin, Voprosy meditsinskoi khimii, 1991, vol: 37(5), 89-92.
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