Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in the replication apparatus and phosphorus-containing metabolite pool in experimental tumors in animals during development

   
Gorbacheva L.B., Gudtsova K.V., Dederer L.Iu., Sokolova I.S., Sibel'dina L.A., Shkarin P.Iu.
PubMed Id: 1812611
Year: 1991 vol: 37  issue:6  pages: 33-36
Abstract: Activity of replicase complex enzymes involving thymidine kinase (TK), ribonucleotide reductase (RR), DNA-polymerases alpha and beta as well as DNA synthesis and single breaks in DNA were studied during growth of P388 ascites tumor. Under these conditions the rate of DNA synthesis was distinctly decreased via salvage pathway and de novo. Single breaks were not detected in the preexistent DNA within various periods after transplantation of P338 leukemic cells. Retardation of DNA synthesis during tumor growth correlated with a decrease in TK, RR and DNA-polymerase alpha activities, while DNA-polymerase beta activity was markedly increased. Growth of melanoma B16 was accompanied by a decrease in content of ATP, ADP, NAD, phosphocreatine and phosphosaccharides as well as by an increase in the level of inorganic phosphates.
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Reference: Gorbacheva L.B., Gudtsova K.V., Dederer L.Iu., Sokolova I.S., Sibel'dina L.A., Shkarin P.Iu., Changes in the replication apparatus and phosphorus-containing metabolite pool in experimental tumors in animals during development, Voprosy meditsinskoi khimii, 1991, vol: 37(6), 33-36.
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