Voprosy meditsinskoi khimii (ISSN 0042-8809)

Biochemical and molecular biological aspects of stomach cancer development in human and animal

   
Khanson K.P., Kalinovskiĭ V.P., Novikov L.B., Fedorov S.N.
PubMed Id: 1812623
Year: 1991 vol: 37  issue:6  pages: 84-88
Abstract: Expression of protooncogenes c-myc, N-myc, c-fos, Ha-ras 1, Ki-ras 2, yes, abl, src, N-ras, met and mos was studied in human gastric tumors and in rat gastric mucosal membrane during gastric carcinogenesis induced in rats by means of N-methyl-N'-nitro-N-nitroso guanidine (MNNG). Elevated expression of protooncogenes c-myc, c-fos, Ha-ras 1, Ki-ras 2, N-myc and Raf 1 was observed in carcinomas of human stomach. Amplification of Ha-ras 1 protooncogene was found in the human gastric tumor and metastasis. Point mutation was not detected in 12 the codon of Ha-ras I protooncogene. Expression of these protooncogenes was not altered during gastric carcinogenesis induced by MNNG in rats. However, within early steps of cancerogenesis (9 days, 3 months) amplification of ribosomal genes occurred in rat gastric mucosal membrane and in adenocarcinoma developed, while the tumor growth was accompanied by activation of mitochondrial genes.
Download PDF:
Reference: Khanson K.P., Kalinovskiĭ V.P., Novikov L.B., Fedorov S.N., Biochemical and molecular biological aspects of stomach cancer development in human and animal, Voprosy meditsinskoi khimii, 1991, vol: 37(6), 84-88.
References
 1995(Vol:41)
 1994(Vol:40)
 1993(Vol:39)
 1992(Vol:38)
 1991(Vol:37)
 1990(Vol:36)
 1989(Vol:35)
 1988(Vol:34)
 1987(Vol:33)
 1986(Vol:32)