Voprosy meditsinskoi khimii (ISSN 0042-8809)

Use of the magnitude of vitamin and vitamin metabolite excretion as indicators of availability of vitamins B2, B6, and niacin

   
Kodentsova V.M., Vrzhesinskaia O.A., Spirichev V.B.
PubMed Id: 1441287
Year: 1992 vol: 38  issue:1  pages: 22-25
Abstract: Alimentary deficiency of riboflavin in rats caused a decrease in excretion of vitamin B2 with urine simultaneously with lowering in daily excretion of 4-pyridoxylic acid (4-PA) and N1-methyl nicotinamide (N1-MNA); these patterns are usually used as indicators of pyridoxine and niacin availability. The similar decrease in excretion of 4-PA and N1-MNA with urine but without alterations in NAD+NADP concentrations in erythrocytes was detected in women deficient in vitamin B2. Content of nicotinamide coenzymes in erythrocytes correlated with excretion of N1-MNA with urine only under normal conditions of riboflavin availability. Use of the criteria involving rates of 4-PA and N1-MNA excretion for evaluation of pyridoxine and niacin deficiency is discussed.
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Reference: Kodentsova V.M., Vrzhesinskaia O.A., Spirichev V.B., Use of the magnitude of vitamin and vitamin metabolite excretion as indicators of availability of vitamins B2, B6, and niacin, Voprosy meditsinskoi khimii, 1992, vol: 38(1), 22-25.
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