Voprosy meditsinskoi khimii (ISSN 0042-8809)

Antioxidants, lipid peroxidation, and receptor-dependent increase in Ca2+ concentration in human platelets

   
Negresku E.V., Lebedev A.V., Baldenkov G.N., Mazaev A.V., Popovich M.I.
PubMed Id: 1441291
Year: 1992 vol: 38  issue:1  pages: 36-39
Abstract: Content of tocopherol and total antiradical activity of hydrophobic antioxidants were estimated in human blood platelets. Two hydrophobic antioxidants--tocopherol and ubiquinone were detected in hexane extracts of thrombocytes using thin-layer chromatography. After incubation of thrombocytes with N-ethyl maleimide content of malonyl dialdehyde was increased and of tocopherol--decreased, receptor-dependent increase of Ca2+ concentration in cytoplasm was potentiated, while the Ca(2+)-blocking effect of nitroglycerol was decreased. Nitroglycerol did not inhibit the N-ethyl maleimide effect on content of malonyl dialdehyde in blood platelets. Addition of exogenous vitamin E to thrombocytes did not affect the receptor-dependent increase of Ca2+ concentration. Ascorbic acid inhibited the receptor-dependent increase of Ca2+ concentration. The data obtained suggest that nitrates may be used more rationally in combination with antioxidants and/or inhibitors of cyclooxygenase.
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Reference: Negresku E.V., Lebedev A.V., Baldenkov G.N., Mazaev A.V., Popovich M.I., Antioxidants, lipid peroxidation, and receptor-dependent increase in Ca2+ concentration in human platelets, Voprosy meditsinskoi khimii, 1992, vol: 38(1), 36-39.
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