Voprosy meditsinskoi khimii (ISSN 0042-8809)

Systemic and regional hemodynamic in rats after use of 5-methoxytryptamine: mechanisms of 'pharmacological adaptation' to hypoxia

   
Platonova R.D., Medvedev O.S.
PubMed Id: 1413634
Year: 1992 vol: 38  issue:2  pages: 53-55
Abstract: Effects of 5-methoxytryptamine (5-MOT) on parameters of systemic and regional hemodynamics were studied in awake Wistar rats. Arterial pressure and pulse were measured using a direct procedure. Content of systolic blood and volume rate of blood flow in 12 vascular zones were estimated by means of the radioactive microsphere technique. The microspheres were inoculated in left heart ventricle under free conditions before, within 30 min and after termination of the 'pharmacological training'. Single intraperitoneal administration of 5-MOT, 25 mg/kg, led to increase in total peripheral resistance by 67% and in cardiac index by 34%. The rate of blood flow was decreased in skin, spleen, kidney and testicular tissues, while it was increased in heart and adrenal glands. 'Pharmacological training', carried out within 9 days with daily administration of 5-MOT 25 mg/kg, resulted in a decrease in total peripheral vascular resistance by 46%, while cardiac index was increased by 97%; blood flow rate was increased in brain, stomach, heart and diaphragm.
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Reference: Platonova R.D., Medvedev O.S., Systemic and regional hemodynamic in rats after use of 5-methoxytryptamine: mechanisms of 'pharmacological adaptation' to hypoxia, Voprosy meditsinskoi khimii, 1992, vol: 38(2), 53-55.
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