Voprosy meditsinskoi khimii (ISSN 0042-8809)

The intracellular second messenger system and its regulatory effects in children with a bronchial asthma attack complicated by heart failure

   
Bakanov M.I., Bershova T.V., Balabolkin I.I., Gerasimov A.A., Mikhailova I.L.
PubMed Id: 1329349
Year: 1992 vol: 38  issue:3  pages: 30-32
Abstract: Components of the intracellular mediators system: calmodulin in leukocytes, Ca2+ and cyclic nucleotides in leukocytes and blood plasma were studied in children with attack of bronchial asthma and heart failure. Alterations in content of these biologically active substances correlated with clinical manifestations of bronchial asthma: severity of the disease, duration of the attack, contractile activity of myocardium. Calmodulin, Ca2+ and cyclic nucleotides were demonstrated to be involved in development of the asthmatic attack. Alterations in the system calmodulin-Ca2+ were related to adaptation and contributed to realization of regulating effects responsible for a decrease of impairments in tissues.
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Reference: Bakanov M.I., Bershova T.V., Balabolkin I.I., Gerasimov A.A., Mikhailova I.L., The intracellular second messenger system and its regulatory effects in children with a bronchial asthma attack complicated by heart failure, Voprosy meditsinskoi khimii, 1992, vol: 38(3), 30-32.
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