Voprosy meditsinskoi khimii (ISSN 0042-8809)

Features of metabolic disorders in the liver during morphine poisoning of various duration

   
Gulyi M.F., Sinitskii V.N., Stognii N.A., Sushkova V.V., Silonova N.V., Shevtsova N.F., Kas'ianova N.N.
PubMed Id: 1413651
Year: 1992 vol: 38  issue:3  pages: 48-50
Abstract: Administration of morphine into rats at a dose of 30 mg/kg within 6 days led to a decrease in total rate of tRNA aminoacylation in liver tissue. Content of lactate, pyruvate, malate and alpha-ketoglutarate was decreased within 6 days-long course of morphine administration, while content of lactate was only altered after 5 weeks of the intoxication. Adaptation reactions appear to be increased with time in long-term intoxication with morphine.
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Reference: Gulyi M.F., Sinitskii V.N., Stognii N.A., Sushkova V.V., Silonova N.V., Shevtsova N.F., Kas'ianova N.N., Features of metabolic disorders in the liver during morphine poisoning of various duration, Voprosy meditsinskoi khimii, 1992, vol: 38(3), 48-50.
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